What is the Zofluza intermediate?

Zofluza intermediate is , while it's Molecular Formula is C 14 H 10 F 2 OS. Used in Pharmaceutical Industry: Zofluza intermediate is used as a key component in the synthesis process for producing Zofluza, a medication intended to combat influenza. Its role is pivotal in the development of the final active pharmaceutical ingredient (API), ensuring the efficacy and safety of the medication in treating influenza in patients above the age of 12. The intermediate's precise function in the synthesis process is tailored to optimize the production of the API, contributing to the overall effectiveness of the drug in inhibiting the replication of the influenza virus and reducing the illness's duration.

What is the CAS number for Zofluza intermediate?

The CAS number of Zofluza intermediate is 1985607-83-7.

What is Zofluza intermediate (1985607-83-7) used for?

Zofluza intermediate is an essential intermediate substance utilized in the synthesis of Zofluza, a prescription medication designed to treat influenza in individuals over the age of 12. Zofluza, also known as Baloxavir Marboxil, functions by inhibiting the replication of the influenza virus, thus alleviating symptoms and shortening the duration of the illness. The specific chemical structure or synthesis process of the Zofluza intermediate remains undisclosed due to the proprietary nature of pharmaceutical manufacturing. As with many pharmaceutical intermediates, it plays a crucial role in refining chemical reactions to yield the final active pharmaceutical ingredient (API).

What is the Zofluza intermediate?

Zofluza intermediate is , while it's Molecular Formula is C 14 H 10 F 2 OS. Used in Pharmaceutical Industry: Zofluza intermediate is used as a key component in the synthesis process for producing Zofluza, a medication intended to combat influenza. Its role is pivotal in the development of the final active pharmaceutical ingredient (API), ensuring the efficacy and safety of the medication in treating influenza in patients above the age of 12. The intermediate's precise function in the synthesis process is tailored to optimize the production of the API, contributing to the overall effectiveness of the drug in inhibiting the replication of the influenza virus and reducing the illness's duration.

What is the CAS number for Zofluza intermediate?

The CAS number of Zofluza intermediate is 1985607-83-7.

What is Zofluza intermediate (1985607-83-7) used for?

Zofluza intermediate is an essential intermediate substance utilized in the synthesis of Zofluza, a prescription medication designed to treat influenza in individuals over the age of 12. Zofluza, also known as Baloxavir Marboxil, functions by inhibiting the replication of the influenza virus, thus alleviating symptoms and shortening the duration of the illness. The specific chemical structure or synthesis process of the Zofluza intermediate remains undisclosed due to the proprietary nature of pharmaceutical manufacturing. As with many pharmaceutical intermediates, it plays a crucial role in refining chemical reactions to yield the final active pharmaceutical ingredient (API).

1985607-83-7

7,8-Difluoro-6,11-dihydro-dibenzo[b,e]thiepin-11-ol

别名：

CasNo.： 1985607-83-7

分子式：

分子量： 264.296

储存条件：

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中文名称： 7,8-Difluoro-6,11-dihydro-dibenzo[b,e]thiepin-11-ol

英文名称： 7,8-Difluoro-6,11-dihydro-dibenzo[b,e]thiepin-11-ol

CasNo.： 1985607-83-7

分子式：

分子量： 264.296

Buy Good Quality 7,8-Difluoro-6,11-dihydro-dibenzo[b,e]thiepin-11-ol 1985607-83-7 with a minimum purity of 99%

Molecular Formula:C₁₄H₁₀F₂OS
Molecular Weight:264.296
Boiling Point:379.5±42.0 °C(Predicted)
PKA:12.57±0.20(Predicted)
Density:1.400±0.06 g/cm3(Predicted)

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1985607-83-7 Process route

: 2136287-66-4
7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-one

: 1985607-83-7
7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepine-11-ol

Conditions

Conditions	Yield
With sodium tetrahydroborate; In ethanol; at 20 - 50 ℃; for 5h; Solvent; Large scale;	98%
With sodium tetrahydroborate; sodium hydroxide; In water; isopropyl alcohol; at 40 ℃; for 1.5h;	97%
With sodium tetrahydroborate; In ethanol; water; Cooling with ice;	97%
With sodium tetrahydroborate; sodium hydroxide; In isopropyl alcohol; at 40 ℃; for 2h;	97%
With sodium tetrahydroborate; water; sodium hydroxide; In isopropyl alcohol; at 0 - 40 ℃;	97%
With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 0.333333h;	97.7%
With sodium tetrahydroborate; sodium hydroxide; In water; isopropyl alcohol; at 40 ℃; for 1.5h;	97%
With sodium tetrahydroborate; sodium hydroxide; In isopropyl alcohol; at 40 ℃; for 4h; Cooling with ice;	95%
With sodium tetrahydroborate; In isopropyl alcohol; at 10 - 55 ℃; Solvent; Temperature;	94.7%
With sodium tetrahydroborate; In methanol; at -10 - 20 ℃; for 4h;	93.2%
With methanol; sodium tetrahydroborate; at -5 - 20 ℃; for 5h;	91.5%
With methanol; sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 1h;
With sodium tetrahydroborate; In isopropyl alcohol; at 40 ℃; for 1h;	1.8 g

: 2136287-66-4
7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-one

: 1985607-83-7
7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepine-11-ol

Conditions

Conditions	Yield
With borane-THF; (S)-5,5-diphenyl-2-methoxy-3,4-propano-1,3,2-oxazaborolidine; In toluene; at 20 - 30 ℃; for 1.5h; Reagent/catalyst; Solvent; Temperature; enantioselective reaction; Inert atmosphere;	93.7%
With EBSDR₈; isopropyl alcohol; NADH; In aq. phosphate buffer; at 30 - 35 ℃; pH=7.2 - 7.5; Enzymatic reaction;	91%
With formic acid; RuCl(p-cymene)[(R,R)-Ts-DPEN]; triethylamine; In tetrahydrofuran; at 60 - 70 ℃; Inert atmosphere;	98.62 % ee

1985607-83-7 Upstream products

455-86-7
3,4-Difluorobenzoic acid
2136287-65-3
3,4-difluoro-2-((phenylthio)methyl)benzoic acid
2136287-66-4
7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-one
930-69-8
sodium thiophenolate

1985607-83-7 Downstream products

1985605-59-1
(R)-12-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-7-hydroxy-3,4,12,12a-tetrahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione

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