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L-(+)-Ergothioneine is a naturally-occurring amino acid derived from histidine via hercynine. Ergothioneine is a stable antioxidant that scavenges and detoxifies free radicals and oxidants, increases intracellular thiol levels, controls nuclear factor-κB activation, and inhibits inflammatory gene expression. In addition, it inhibits the peroxynitrite-dependent nitration of nitrotyrosine, blocks oxidative DNA damage and cell death, and prevents the formation of xanthine and hypoxanthine. Ergothioneine is transported by the organic cation/carnitine transporter 1, which has been linked with autoimmune diseases, including rheumatoid arthritis and Crohn’s disease.
The CAS number of L-(+)-ERGOTHIONEINE is 497-30-3.
Synonyms for L-(+)-ERGOTHIONEINE 497-30-3:1H-Imidazole-4-ethanaminium,a-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-,hydroxide, inner salt, (S)-;Ammonium,[1-carboxy-2-(2-mercaptoimidazol-4-yl)ethyl]trimethyl-, hydroxide, inner salt,L-(+)- (8CI);1H-Imidazole-4-ethanaminium, a-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, innersalt, (S)-;2-Mercapto-N,N-dimethylhistidine methyl ester betaine;2-Mercaptohistidine betaine;2-Mercaptohistidine trimethylbetaine;Ergothioneine;
L-(+)-Ergothioneine is a natural molecule isolated from the rye ergot fungus and later identified in rat erythrocytes and liver and in numerous other animal tissues. Its antioxidizing properties may afford the compound therapeutic potential or it may be used as a food additive or in cosmetics.
InChI:InChI=1/C9H15N3O2S/c1-12(2,3)7(8(13)14)4-6-5-10-9(15)11-6/h5,7H,4H2,1-3H3,(H2-,10,11,13,14,15)/t7-/m0/s1
Relevant articles related to L-(+)-ERGOTHIONEINE:
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Synthesis method of ergothioneine |
- Paragraph 0007; 0037-0038, (2020/09/09) |
In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C-S Lyase and Methyltransferase Reactions |
Naowarojna, Nathchar,Huang, Pei,Cai, Yujuan,Song, Heng,Wu, Lian,Cheng, Ronghai,Li, Yan,Wang, Shu,Lyu, Huijue,Zhang, Lixin,Zhou, Jiahai,Liu, Pinghua , p. 5427 - 5430 (2018/09/12) |
Nα, Nα, Nα-trialkyl histidine derivatives useful for the preparation of ergothioneine compounds |
- Page/Page column 22, (2016/09/26) |
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