What is the Troparil?

Troparil is , while it's Molecular Formula is C 16 H 21 NO 2 . Troparil is used in scientific research into the dopamine reuptake transporter. 3H-radiolabelled forms of troparil have been used in humans and animals to map the distribution of dopamine transporters in the brain. It is also used for animal research into stimulant drugs as an alternative to cocaine which produces similar effects, but avoids the stringent licensing requirements for the use of cocaine itself.

What is the CAS number for Troparil?

The CAS number of Troparil is 74163-84-1.

What is Troparil (74163-84-1) used for?

Troparil is a phenyltropane-based dopamine reuptake inhibitor that is derived from methylecgonidine. It is a stimulant drug used in scientific research. The most commonly used form of troparil is the tartrate salt, but the hydrochloride and naphthalenedisulfonate salts are also available, as well as the free base.InChI:InChI=1/C16H21NO2/c1-17-12-8-9-14(17)15(16(18)19-2)13(10-12)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14+,15-/m0/s1

What is the Troparil?

Troparil is , while it's Molecular Formula is C 16 H 21 NO 2 . Troparil is used in scientific research into the dopamine reuptake transporter. 3H-radiolabelled forms of troparil have been used in humans and animals to map the distribution of dopamine transporters in the brain. It is also used for animal research into stimulant drugs as an alternative to cocaine which produces similar effects, but avoids the stringent licensing requirements for the use of cocaine itself.

What is the CAS number for Troparil?

The CAS number of Troparil is 74163-84-1.

What is Troparil (74163-84-1) used for?

Troparil is a phenyltropane-based dopamine reuptake inhibitor that is derived from methylecgonidine. It is a stimulant drug used in scientific research. The most commonly used form of troparil is the tartrate salt, but the hydrochloride and naphthalenedisulfonate salts are also available, as well as the free base.InChI:InChI=1/C16H21NO2/c1-17-12-8-9-14(17)15(16(18)19-2)13(10-12)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14+,15-/m0/s1

74163-84-1

Troparil

Another Name：

CasNo.： 74163-84-1

MF： C16H21 N O2

MW： 259.348

Storage：

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ch_Name： Troparil

English name： Troparil

CasNo.： 74163-84-1

MF： C16H21 N O2

MW： 259.348

99% Purity Commercial production Troparil 74163-84-1 with Cheapest Price

Molecular Formula:C₁₆H₂₁NO₂
Molecular Weight:259.348
Vapor Pressure:4.47E-05mmHg at 25°C
Refractive Index:1.54
Boiling Point:350.2°C at 760 mmHg
PKA:9.95±0.60(Predicted)
Flash Point:121.3°C
PSA：29.54000
Density:1.099g/cm³
LogP:2.36380

Troparil(Cas 74163-84-1) Usage

Pharmacokinetics

Troparil is a few times more potent than cocaine as a dopamine reuptake inhibitor, but is less potent as a serotonin reuptake inhibitor, and has a duration spanning a few times longer, since the phenyl ring is directly connected to the tropane ring through a non-hydrolyzable carbon-carbon bond. The lack of an ester linkage removes the local anesthetic action from the drug, so troparil is a pure stimulant. This change in activity also makes troparil slightly less cardiotoxic than cocaine.

InChI:InChI=1/C16H21NO2/c1-17-12-8-9-14(17)15(16(18)19-2)13(10-12)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14+,15-/m0/s1

74163-84-1 Relevant articles

Synthesis, radiosynthesis and first in vitro evaluation of novel PET-tracers for the dopamine transporter: [11C]IPCIT and [ 18F]FE@IPCIT

Rami-Mark, Christina,Bornatowicz, Birgit,Fink, Cornel,Otter, Paul,Ungersboeck, Johanna,Vraka, Chrysoula,Haeusler, Daniela,Nics, Lukas,Spreitzer, Helmut,Hacker, Marcus,Mitterhauser, Markus,Wadsak, Wolfgang

, p. 7562 - 7569 (2014/01/06)

Introduction Present data indicate that ...

Synthesis, ligand binding, QSAR, and CoMFA study of 3β-(p-substituted phenyl)tropane-2β-carboxylic acid methyl esters

Carroll,Gao,Rahman,Abraham,Parham,Lewin,Boja,Kuhar

, p. 2719 - 2725 (2007/10/02)

A series of 3β-(p-substituted phenyl)tro...

Compounds affecting the central nevous system.4. 3B-phenyltropane-2-carboxylic esters and analogs

Clarke et al.

, p. 1260,1262 (2007/10/04)

74163-84-1 Process route

: 100-58-3
phenylmagnesium bromide

: 50373-10-9
methyl ecgonidine

: 50370-54-2,50372-80-0,50583-05-6,57458-42-1,74163-83-0,74163-84-1,127379-25-3,127379-26-4
(1R,3S,5S)-8-Methyl-3-phenyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
phenylmagnesium bromide; methyl ecgonidine; In diethyl ether; dichloromethane; at -78 - -40 ℃; for 3.5h; Inert atmosphere; With trifluoroacetic acid; In diethyl ether; dichloromethane; Inert atmosphere;	65.28%

: cocaine HCl

: 50370-54-2,50372-80-0,50583-05-6,57458-42-1,74163-83-0,74163-84-1,127379-25-3,127379-26-4
(1R,3S,5S)-8-Methyl-3-phenyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: hydrogenchloride / 6 h / Reflux 1.2: 4 h / Reflux; Inert atmosphere 1.3: -40 - 20 °C 2.1: dichloromethane; diethyl ether / 3.5 h / -78 - -40 °C / Inert atmosphere 2.2: Inert atmosphere With hydrogenchloride; In diethyl ether; dichloromethane;

74163-84-1 Upstream products

100-58-3
phenylmagnesium bromide
50373-10-9
methyl ecgonidine
50373-10-9
(R)-(-)-anhydroecgonine methyl ester

74163-84-1 Downstream products

127379-27-5
methyl (1R-2-exo-3-exo)-8-methyl-3-(4-nitrophenyl)-8-azabicyclo<3.2.1>octane-2-carboxylate
127279-72-5
methyl (1RS-2-endo-3-exo)-3-(2,4-dinitrophenyl)-8-methyl-8-azabicyclo<3.2.1>octane-2-carboxylate
127279-73-6
methyl (1RS-2-exo-3-exo)-8-methyl-3-(4-nitrophenyl)-8-azabicyclo<3.2.1>octane-2-carboxylate
135367-05-4
3β-(4-ethoxycarboxamidophenyl)tropane-2β-carboxylic acid methyl ester